产品货号：
GS4394
中文名称：
重组人IFN-γ
英文名称：
Recombinant Human Interferon-gamma
产品规格：
20μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 16.9kDa,a single non-glycosylated polypeptide chain containing 144 amino acids.
储存条件：冷冻（-20℃）
概述
Interferon-gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.Human IFN-γ is highly species specific and is biologically active only in human and primate cells.IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IFN-γ，IFN-γ, Human，Recombinant Human Interferon-gamma
储存条件：冷冻（-20℃）
概述
Interferon-gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.Human IFN-γ is highly species specific and is biologically active only in human and primate cells.IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞98%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cytotoxicity assay using HT-29 cells is less than 0.05ng/ml,corresponding to a specific activity of>2.0×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIFN-γ as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRGR RASQ |
相关搜索：重组人IFN-γ，IFN-γ, Human，Recombinant Human Interferon-gamma